[Serum copper and zinc level in patients suffering from infectious mononucleosis and after the regression of clinical symptoms]. / Stezenie miedzi i cynku w surowicy oraz wartosc wskaznika miedziowo-cynkowego w przebiegu mononukleozy zakaznej i po ustapieniu objawów klinicznych.

UNLABELLED: The aim of this work was to assess the serum copper (Cu) and zinc (Zn) level and ratio Cu/Zn in the acute, symptomatic period of infectious mononucleosis and during the convalescence period, when no clinical symptoms were present. MATERIAL AND METHODS: We examined 50 persons, including 26 patients (14 women and 12 men) in the age of 16 to 27 years, examined in the acute, symptomatic period of the disease. The diagnosis of infectious mononucleosis was based on the clinical, haematological, biochemical and serologic criteria. Cu and Zn concentration was measured 3 times: on the 1st day and the 2nd week of hospitalisation, and also after the regression of clinical symptoms. The control group consisted of 24 healthy individuals (13 men and 11 women) in the age of 17 to 26 years. Cu and Zn concentration was measured once in this group. All measurements of Cu and Zn serum concentration were done using the method of atomic absorption spectrophotometry (AAS) with AAS-3 spectrophotometer of Carl Zeiss-Jena production, at the wavelength for Cu--324.8, Zn--213.9 nm. We observed the Cu and Zn serum concentration and ratio Cu/Zn in patients with acute, symptomatic infectious mononucleosis and also after the regression of clinical symptoms to be statistically higher that the results from the healthy individuals. CONCLUSION: The statistical significant elevated serum Cu and Zn concentration observed during the course of infectious mononucleosis and after clinical symptoms regression in comparison to healthy persons expressed the perturbation of trace elements homeostasis. If copper to zinc ratio reflects myeloproliferative diseases activity, the practical value for infectious mononucleosis monitoring is the same as copper and zinc serum level measurement.

Candidosis of the pharyngeal mucosa in patients with infectious mononucleosis.

The aim of our study was to assess the frequency rate of Candida yeast-like fungi in isolations from nasal and pharyngeal mucosa in patients diagnosed with IM who had undergone an antibiotic therapy. The study was performed in 51 patients aged 17-33. The diagnosis of IM was made on the basis of clinical symptoms, haematological, biochemical and serologic examination results. The material constituted of nasal and pharyngeal swabs. The identification of Candida species was done according to the routine microbiological diagnostics. Our results show that among the Candida genus, C. albicans was the only pathogenic species isolated from patients with IM. It was observed only in pharyngeal swabs in 27.4% of the patients.

Dynamics of proinflammatory cytokines serum levels during viral hepatitis type A.

In this study we assessed the dynamics concerning IL-2, sLL-2R and IL-4 serum levels in the course of an acute viral hepatitis A infection. The study group consisted of 48 persons. The serum concentrations of IL-2, sIL-2R and IL-4 were assessed with the use of ELISA methods. In patients the assessments were done twice--in the first and third week of the hospitalisation. In the control group, which consisted of 24 healthy persons the assessments were done once. The obtained data were analysed with the use of c-Cochran and Cox statistical test. We observed a statistically important decrease in IL-2 and IL-4 serum levels in patients with acute viral hepatitis A infection in the first week of the hospitalisation compared to values observed in the control group. We also observed an increase in sIL-2R levels in the course of the disease. The dynamics of IL-2, sIL-2R and IL-4 serum levels in patients with acute hepatitis A infection was of a random type. The assessment of IL-2, sIL-2R and IL-4 serum levels can be helpful in examining the cellular response in viral hepatitis A infection.

[Dynamics of changes in magnesium (Mg) serum levels in patients suffering from infectious mononucleosis]. / Ocena dynamiki zmian poziomu magnezu (Mg) w surowicy krwi chorych na mononukleoze zakazna.

The aim of the study was to assess the dynamics of changes in magnesium (Mg) serum levels in the acute, symptomatic period of infectious mononucleosis and during the convalescence period, when clinical symptoms were no longer present. 50 subjects were included, among them 26 patients (14 women and 12 men) at the age of 16 to 27 years in the acute, symptomatic stage of the disease. The diagnosis of infectious mononucleosis was based on the clinical, hematological, biochemical and serologic criteria. Mg concentration was measured 3 times: on the 1st day and in the 2nd week of hospitalization, and also in the convalescence period--3 weeks after the regression of clinical symptoms. The control group consisted of 24 healthy individuals (5 men and 5 women) at the age of 17 to 26 years. Mg concentration was measured once in this group. All measurements of Mg serum concentration were performed using the method of atomic absorption spectrophotometry (AAS) at the wavelength of 285.2 nm. We observed significantly higher Mg serum concentrations in patients with acute, symptomatic infectious mononucleosis than in healthy individuals. During the convalescence period Mg serum concentrations were lower but still statistically higher than in the control group.

Copper/zinc ratio in measles patients.

UNLABELLED: The aim of this study was to evaluate the serum copper (Cu), zinc (Zn) levels and Cu/Zn ratio in measles patients in comparison to the control group. The study was conducted on 26 patients. The serum Cu and Zn levels were determined three times using atomic absorbtion spectrometry. The control group included 24 healthy persons. The serum Cu and Zn levels in those persons were determined once. CONCLUSION: in the acute period of the disease, a significant and highly significant increase in Cu/Zn ratio takes place.

[Ramsay Hunt syndrome--a case study]. / Zespól Ramsaya Hunta--opis przypadku.

In this work we present a patient, aged 40 with Ramsay Hunt syndrome, who was treated at the Department of Infectious Disease, Medical Academy in Lublin (Poland). The diagnosis of the disease was based on the anamnesis concerning epidemiology of the disease, the course and three major symptoms: facial paralysis, neuralgia, herpetic eruption in the mouth and on the ear. The combined treatment with antiviral drugs and corticosteroids was partially successful and did not resolve the seventh nerve palsy.

[Profile of microorganisms isolated in nasopharyngeal swabs from the patients with acute infectious mononucleosis]. / Charakterystyka drobnoustrojów izolowanych z blon sluzowych jamy nosowo-gardlowej u chorych z mononukleoza zakazna.

Infectious mononucleosis is a self-limiting lymphoproliferative disorder, which contribute to the development of the various clinical symptoms. Exudative tonsillitis was found to be caused by Epstein-Barr virus in 19% of all viral infections and may imitate a bacterial etiology. The aim of this study was to identify the microbes from the nasopharyngeal swabs obtained from the patients with exudative tonsillitis and to assess their susceptibility to antibiotics. The patients were hospitalized as an infectious mononucleosis after unsuccessful antibiotic therapy. 84 patients were investigated: group I--patients with serological positive infectious mononucleosis tests and group II--patients with acute exudative tonsillitis and with serologically excluded infectious mononucleosis. The diagnosis was confirmed clinically, haematologically, biochemically and serologically. Nasopharyngeal specimens were taken, once, at the first day of hospitalization. Then, routine microbiological assays were performed. Isolated strains were identified biochemically: API Strep, API Staph, API E, API Ne, APINH (bioMerieux). The susceptibility to antibiotics with an agar diffusion assay was performed according to Kirby-Bauer. We concluded that various, potentially pathogenic bacterial flora was found in throat during infectious mononucleosis. Haemophilus spp. and Staphylococcus aureus MSSA were isolated more frequently. Haemophilus influence was susceptible to cefotaxime and azytromycine. Candida albicans was isolated in every fourth patient. Streptococcus pyogenes as an etiological agent of exudative tonsillitis was confirmed in the group II. The pharyngeal candidiosis was also observed more frequently in the group II.